Atherosclerosis, often called “hardening of the arteries” is an accumulation of “junk” in the arteries, which become blocked and inhibit the flow of blood. The cause of atherosclerotic plaque build up is a complicated process, involving the retention of oxidized LDL cholesterol and other fibrous materials. Inflammation is a major player in the build up of plaque. Resveratrol can help relieve plaque and inhibit its formation by several different means:
Vasodilation and Artery Elasticity
Resveratrol stimulates the production of substances in the body, such as nitric oxide (NO), which make the arteries more elastic. The more flexible the arteries, the more they can withstand differences in blood pressure and even decrease blood pressure.
Oxidative Stress
Resveratrol, a powerful antioxidant, helps reduce oxidation of LDL cholesterol, which makes it less sticky and prone to developing into plaque. Resveratrol also stimulates the body’s production of glutathione, a critical free-radical scavenger, which inhibits oxidation.
Anti-inflammatory activity
Inflammation is a major player in the buildup of plaque. The anti-inflammatory properties of resveratrol help it to reduce plaque development and keep the arteries flowing.
Suppression of Platelet Aggregation
One of the key players in atherosclerosis is the platelet, a blood cell that is important for clotting. Platelets adhere to injured arterial cells. The accumulate and can cause serious blockage. Resveratrol inhibits the buildup of platelets on the arterial walls.
With all this taken into account, it is probably a good idea to supplement your diet with a good source of resveratrol.
Fan et al. 2008. Beneficial Effects of Resveratrol on Atherosclerosis. J. Med. Food 11 (4).2008. 610-614.




