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Insightful perspectives and sage advice from Dr. Jonathan Selzer, lead research scientist at HerbaSway. This is the place to stay current with the latest developments in dietary and nutritional supplements. Feel free to join the discussion to share your own opinions and experiences!
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Coenzyme Q10: Not So Hard To Swallow

May 13th, 2009
by drselzer

CoQ10 comes in many forms. Most commonly found on the market is a capsule or tablet. The liquid forms of the product are in the minority. There are, however, major difference among the different types.

One recent study from Korea studied the bioabsorption of different capsules and tablets. They found that major differences in the amount of coQ10 in the blood stream occur among the different brands. This had primarily to do with the so-called dissolution rate, or the time it takes for a capsule or table to dissolve in the stomach and release its contents, making them available for absorption. Liquids, of course, do not need to dissolve and are immediately available for absorption.

Comparison of bioavailability of two ubidecarenone products in healthy Korean volunteers. Kang EY, Choi JW, Gwak HS, Chun IK. Int J Clin Pharmacol Ther. 2009 Mar;47(3):207-14.

On a personal note, I take HerbaSway’s Liquid CoQ10 straight from the pipette. I like the intense taste better than when it is dissolved in water. It is also not bad in milk, though.

Toxins and Your Liver

May 8th, 2009
by drselzer

Detoxification

 

Toxic substances enter out bodies through several venues: the air we breathe, the food we eat, the water we drink, the medications we swallow and the chemicals we apply to our skin. In the course of normal metabolism, you body creates toxins from the chemicals it uses to do its job. The toxins enter your body by one means or another, are transported by blood and lymph throughout the body, and are either deposited in certain susceptible cells or chemically modified by, for example cells in the liver.

 

How Toxins Work; Why They Are Bad

 

The toxins can attack all cells in the body and have very different means of destruction. Some compete with natural bodily substances, interrupting the chain of communication. This can result in a disturbed metabolism, an imbalance in the system, with terrible consequences.  Examples are changes in hormonal balance, which can lead to certain kinds of cancer. Other examples are immunological disorders such as the development of allergies and autoimmune diseases.

 

Other toxins act by killing cells directly. This can occur when, for example, free radicals are released and damage the mitochondria, the microscopic parts of cells responsible for the production of energy. Without energy, metabolic processes shut down and the cells die. When enough cells have been lost, the tissue and finally the organs lose their functions and can die.

 

These mechanisms combine to gradually weaken the organism. The constant attack on our bodies from environmental toxins strains and weakens in particular the immune system. This opens the body to more successful infections by microorganisms, causes immunological problems, etc. In time, the system becomes so weakened that it crashes. Debilitating disease can ensue.

 

In other words, toxins contribute to the aging process, which can be observed both internally and externally. For example, heavy smokers suffer from advanced aging on the skin. This is in part due to the toxins and in particular the oxidative stressors that enter their bodies through the lungs.

 

 

The Liver To The Rescue

 

The Three Stages of Detoxification

The liver is the toxin clearing house of the body. In the initial phase of detoxification, the liver breaks down the toxic chemicals into less harmful forms. This process can, however, generate free-radicals, which can damage liver cells. In the absence of antioxidants, the free-radicals can actually destroy the mitochondria of liver cells causing their eventual death.

 

The second stage of detoxification, the conjugation pathway, consists of the fusing of the broken molecules of stage one with other substances. This lowers their toxicity even more and prepares them for the third stage, the passage through the liver and elimination from the body via the bowels or kidneys.

 

The prerequisite for this complicated procedure is a healthy, functioning liver.

 

We can help our livers by eating a well balanced diet and including some specific foods and supplements, which support liver function. Antioxidants are very important to minimize the cellular destruction from free-radicals. Milk thistle, medicinal mushrooms and other herbs helps support liver function. Other foods, which deliver active phytochemicals to support liver health are broccoli and cabbages, garlic and onions. Including large amounts of fiber in our diets can help the body rid itself of toxins after they have been degraded by the liver.

Oxidation in the eye

May 4th, 2009
by drselzer

Your retina consumes more oxygen than any other tissue in your body, making it particularly susceptible to oxidative damage. On top of that, the retina is exposed to high levels of light, another source of oxidative stress in the eye. Furthermore, the high concentrations of polyunsaturated fatty acids in eye membranes are particularly susceptible to oxidation.

 

Your eyes require tremendous amounts of chemical energy, produced in the mitochondria as ATP. As we have seen over and over again, oxidation of the mitochondria leads to a decrease in its ability to produce energy. This results in a loss of cell function, leading to macular degeneration and loss of vision. It is a wonder that you can still see!

 

Vitamin E is present at high levels in the eyes. It has two functions: vitamin E is an integral component of the membranes and it protects against oxidation. Coenzyme Q10 is also concentrated in the eyes. It protects the membranes from oxidation and the mitochondria from DNA damage caused by oxidation. In fact, it has been shown that coenzyme Q10 supports the vitamin E synergistically in its fight against oxidation.

 

Although it is not known whether vitamin E levels decrease with age, this is certainly true with Coenzyme Q10. The older you get, the more you need to take coenzyme Q10.

 

Qu J et al. 2009. Coenzyme Q10 in the human retina.  Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1814-8.

 

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