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Insightful perspectives and sage advice from Dr. Jonathan Selzer, lead research scientist at HerbaSway. This is the place to stay current with the latest developments in dietary and nutritional supplements. Feel free to join the discussion to share your own opinions and experiences!
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Coenzyme Q10 reduces medication’s toxicity

April 30th, 2009
by drselzer

Amitriptyline is a pharmaceutical often prescribed to treat depression.

 

Some of the serious side effects of this drug are a disruption of your cell’s mitochondrial function, an increase in cellular oxidative stress and a decrease in the production of coenzyme Q10. The result was accelerated cell death. We also know that the mitochondria are responsible for producing the energy we need to run the body machine. Sick mitochondria cannot produce the energy required, leading to serious weakening of organ function.

 

Scientists from Sevilla, Spain have just published their results on the use of dietary coenzyme Q10 and natural vitamin E to treat and prevent the toxic effect of amitriptyline. They found that both antioxidants, Q10 and vitamin E helped to protect the mitochondria and to compensate for the decreased production of Q10.

 

Cordero MD, et al. 2009. Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicity. Toxicol Appl Pharmacol. 2009 Mar 15;235(3):329-37.

 

One of the reasons we combined coenzyme Q10 and vitamin E in our Liquid CoQ10 product is to provide the absolute optimum protection. Click here for more information about this effective and delicious product.

How Chocolate is Made and How the Process Affects the Health Benefits.

April 21st, 2009
by drselzer

Take a chocolate bean and bite into it. Yuch! You would never know that this bean can produce some of the most delicious foods on earth. The process of turning this unpalatable bean into the product of a French chocolatier is long and complicated. In fact, the process is often a diligently guarded trade secret and everyone has their own methods. Not only is the taste of the chocolate affected by the process used, but also the health benefits from the flavonoids.

As expected, each step along the way has an influence on the
flavonoid content of the chocolate. Similarly to teas, the amount of
fermentation determines the polyphenol content. Green tea is unfermented; it has the highest polyphenol content and the most EGCG of all teas. Black tea is thoroughly fermented and has the lowest content. Oolong is somewhere in between. The same is true for chocolate. The less the fermentation, the higher the flavonol content.

The first step after harvesting is to let the beans ferment. For seven days, the beans are turned and aerated, as different fermentation
processes occur together or in succession.

After fermentation, the beans are dried and cleaned to avoid spoilage. Then they are roasted, subjected to temperatures of 120 – 150C. This causes many changes to the beans: the roasted parts can be separated from the shell, the
sugars are caramelized, other chemical reactions occur with the many amino acids and peptides in the beans. Most of the taste
nuances develop during the roasting process. The polyphenol
flavonoids are also changed during the roasting process.

The next step is a vigorous shaking or winnowing. This separates out the shells and breaks the cocoa into nibs, or small pieces. These are
actually edible. They can, if desired, be re roasted to improve flavor.

The next stage that can alter the flavonoid content is milling. The nibs, which contain high fat content, are ground into a fine powder. Because of the 50% or more of fat, the cocoa becomes liquefied as temperatures rise again during the milling process. This tends to decrease and change the flavonoid composition. Also, further refining can be done, such as separating the cocoa fat from the cocoa solids. Food additives are added to the mixture now to achieve certain desired results.

Acids, which develop in the cocoa during the fermentation process must be removed. This can be achieved with a process called conching, or grinding under mild heat, or through the process of dutching, or treating with a mild basic solution. Dutching removes a large portion f the flavonoids.

Products, such as HerbaSway’s Crème de Chocolat is made with undutched cocoa powder and an extract made from unfermented beans. This insures the best possible mixture of cocoa polyphenols and their health benefits.

Eat Chocolate For Study Aid

April 8th, 2009
by drselzer

The wonders of chocolate never cease to amaze! Researchers in England studied the effects of cocoa polyphenols on people’s ability to concentrate and think. The results add to a growing pool of evidence that cocoa polyphenols have health benefits for many conditions.

The placebo controlled study had adults drinking a high cocoa flavanol beverage before performing mental tasks in arithmetic. Those drinking the cocoa performed significantly better than those taking the placebo control. They also suffered less fatigue after the exercise.

I know now that I should give my children lots of Crème de Chocolat before their exams at school. This is a sugar-free, fat-free and calorie-free liquid dietary supplement might will help them get good grades!

The results were presented at symposium in the UK and corroborate a study we discussed on March 24th.

Chocolate Recovery

April 6th, 2009
by drselzer

Sports drinks are omnipresent. Everywhere you turn, you might find a new product claiming isotonic or carbohydrate enriched or both, designed to help athletes recover from exercise.

 

A new study by Thomas et al 2009 compared the parameters of recovery in healthy cyclists who drank either an isotonic sports drink, a carbohydrate sports drink or chocolate milk. I am sure that you can guess which material yielded the best results: the chocolate milk.

 

The authors of the study compared the natural sugars and fats of the chocolate milk with those of the sports drinks and found plausible explanations in both of these components. I think that more investigations is necessary to understand the role that the cocoa polyphenols play in muscle recovery. My suspicion is that the polyphenols from the chocolate are very important to the recovery and work synergistically with the carbohydrates and fats to optimize it.

 

Thomas K, et al. 2009. Improved endurance capacity following chocolate milk consumption compared with 2 commercially available sport drinks. Appl Physiol Nutr Metab. 2009 Feb;34(1):78-82.

 

Resveratrol and Pancreatic Beta Cells

April 3rd, 2009
by drselzer

Diabetes is associated with a loss of pancreatic beta cells, which secrete insulin. Insulin is critical to maintaining blood sugar levels. Insulin tells your body’s cells to take up glucose from the blood and store it as a substance called glycogen. It also signals your  body not to use fats as a source of energy, but instead to burn up carbohydrates. Diabetes is characterized, therefore, by a loss if insulin (type I) or cells that are “resistant” to insulin (i.e. do not listen to the signals) although it remains present in the cells (type II). In either case, the results can be deadly.

The Sirt1 enzymes, known as  key players in cellular defense and survival under stress conditions, can help. We do not yet know how it works, but the Sirt1 enzymes protect the pancreatic beta cells. The protected cells can then perform their regular job: keep the blood sugar levels in balance.

Resveratrol has been shown to stimulate the production and/or activity of the Sirt1 enzymes. Thus, it appears, resveratrol can help protect the pancreatic beta cells from destruction. The authors of this new study from Korea conclude that resveratrol might be used to treat the Type I diabetes patients.

Ji-Hyun Lee et al. 2009. Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-B Signaling Pathway. Diabetes 58:344-351, 2009

 

 

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